Dynamic Chemical Life Science（Hori Lab.）

In our laboratory, we are developing chemical biology techniques to label and visualize proteins with synthetic fluorescent molecules by devising and applying chemical principles. In living cells, countless biomolecules exist, dynamically changing their localization and controlling cellular events by performing the biomolecular functions in a subcellular region where they are needed. Visualization of the movement of these biomolecules provides important information to elucidate the physiological functions they control. We have developed original technology for fluorescent labeling of proteins to reveal how proteins move in living cells and regulate biological phenomena. Furthermore, we aim to elucidate biological phenomena regulated by nucleic acids, glycans, and extracellular vesicles in addition to proteins, and to control functions of biomolecules and cells at will by making full use of our protein labeling technology.